BH3 mimetic ABT-737 induces apoptosis in CD34<sup>+</sup> acute myeloid leukemia cells and shows synergistic effect with conventional chemotherapeutic drugs.

Rao, Jia; Li, Fei; Zhang, Rong-Yan; Zhou, Huan-Huan; Chen, Guo-An

BH3 mimetic ABT-737 induces apoptosis in CD34⁺ acute myeloid leukemia cells and shows synergistic effect with conventional chemotherapeutic drugs.

Rao, Jia; Li, Fei; Zhang, Rong-Yan; Zhou, Huan-Huan; Chen, Guo-An.

Afiliação

Rao J; Department of Hematology, First Affiliated Hospital, NanChang University, Nanchang, China.
Li F; Department of Hematology, First Affiliated Hospital, NanChang University, Nanchang, China.
Zhang RY; Department of Hematology, First Affiliated Hospital, NanChang University, Nanchang, China.
Zhou HH; Department of Hematology, First Affiliated Hospital, NanChang University, Nanchang, China.
Chen GA; Department of Hematology, First Affiliated Hospital, NanChang University, Nanchang, China.

Asia Pac J Clin Oncol ; 13(2): e144-e152, 2017 Apr.

Article em En | MEDLINE | ID: mdl-26552712

Assuntos

Apoptose/efeitos dos fármacos; Compostos de Bifenilo/metabolismo; Genes bcl-2/fisiologia; Leucemia Mieloide Aguda/metabolismo; Nitrofenóis/metabolismo; Sulfonamidas/metabolismo; Adulto; Sinergismo Farmacológico; Feminino; Humanos; Leucemia Mieloide Aguda/patologia; Masculino; Pessoa de Meia-Idade; Piperazinas/metabolismo; Adulto Jovem

Palavras-chave

ABT-737; Bcl-2; acute myeloid leukemia; apoptosis

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Leucemia Base de dados: MEDLINE Assunto principal: Sulfonamidas / Compostos de Bifenilo / Leucemia Mieloide Aguda / Apoptose / Genes bcl-2 / Nitrofenóis Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Asia Pac J Clin Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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