The effect of dose escalation on gastric toxicity when treating lower oesophageal tumours: a radiobiological investigation.
Radiat Oncol
; 10: 236, 2015 Nov 19.
Article
em En
| MEDLINE
| ID: mdl-26586375
ABSTRACT
PURPOSE:
Using radiobiological modelling to estimate normal tissue toxicity, this study investigates the effects of dose escalation for concurrent chemoradiation therapy (CRT) in lower third oesophageal tumours on the stomach. METHODS AND MATERIALS 10 patients with lower third oesophageal cancer were selected from the SCOPE 1 database (ISCRT47718479) with a mean planning target volume (PTV) of 348 cm(3). The original 3D conformal plans (50 Gy3D) were compared to newly created RapidArc plans of 50 GyRA and 60 GyRA, the latter using a simultaneous integrated boost (SIB) technique using a boost volume, PTV2. Dose-volume metrics and estimates of normal tissue complication probability (NTCP) were compared.RESULTS:
There was a significant increase in NTCP of the stomach wall when moving from the 50 GyRA to the 60 GyRA plans (11-17 %, Wilcoxon signed rank test, p = 0.01). There was a strong correlation between the NTCP values of the stomach wall and the volume of the stomach wall/PTV 1 and stomach wall/PTV2 overlap structures (R = 0.80 and R = 0.82 respectively) for the 60 GyRA plans.CONCLUSION:
Radiobiological modelling suggests that increasing the prescribed dose to 60 Gy may be associated with a significantly increased risk of toxicity to the stomach. It is recommended that stomach toxicity be closely monitored when treating patients with lower third oesophageal tumours with 60 Gy.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Esofago
/
Tratamento
/
Radioterapia
Base de dados:
MEDLINE
Assunto principal:
Estômago
/
Planejamento da Radioterapia Assistida por Computador
/
Neoplasias Esofágicas
/
Radioterapia Conformacional
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Radiat Oncol
Assunto da revista:
NEOPLASIAS
/
RADIOTERAPIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido