The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat.
J Radiat Res
; 57(2): 127-32, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-26811259
ABSTRACT
The aim of this study was to investigate the effect of continuous extremely low frequency magnetic fields (ELF-MFs) with a frequency of 10 Hz and an intensity of 690-720 µT on the level of 5-hydroxyindolacetic acid (5-HIAA) in adult male Wistar rats. A total of 24 adult Wistar male rats were used, and after exposure with an ELF-MF for 15 successive days, all rats in each test were anesthetized with chloral hydrate. Then, they were placed in a stereotaxic frame for surgery and a microdialysis process. Dialysate samples were analyzed to measure the amount of 5-HIAA by high performance liquid chromatography (HPLC) using electrochemical detection. Results showed that ELF-MF exposure for 15 days, 1 h daily, was not effective in altering the level of 5-HIAA. However, ELF-MF exposure for 15 days, 3 h daily, decreased the level of the 5-HIAA in the raphe nucleus. It can be concluded that ELF-MFs affect the serotonergic system and may be used to treat nervous system diseases. This study is an initial step towards helping cure depression using ELF-MFs.
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Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Núcleos da Rafe
/
Campos Magnéticos
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Ácido Hidroxi-Indolacético
Limite:
Animals
Idioma:
En
Revista:
J Radiat Res
Ano de publicação:
2016
Tipo de documento:
Article