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Antitumour activity of the glycoengineered type II anti-CD20 antibody obinutuzumab (GA101) in combination with the MDM2-selective antagonist idasanutlin (RG7388).
Herting, Frank; Herter, Sylvia; Friess, Thomas; Muth, Gunther; Bacac, Marina; Sulcova, Jitka; Umana, Pablo; Dangl, Markus; Klein, Christian.
Afiliação
  • Herting F; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Munich, Germany.
  • Herter S; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland.
  • Friess T; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Munich, Germany.
  • Muth G; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Munich, Germany.
  • Bacac M; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland.
  • Sulcova J; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland.
  • Umana P; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland.
  • Dangl M; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Munich, Germany.
  • Klein C; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland. christian.klein.ck1@roche.com.
Eur J Haematol ; 97(5): 461-470, 2016 Nov.
Article em En | MEDLINE | ID: mdl-26993060
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Pirrolidinas / Proteínas Proto-Oncogênicas c-mdm2 / Anticorpos Monoclonais Humanizados / Para-Aminobenzoatos / Anticorpos Monoclonais / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Eur J Haematol Assunto da revista: HEMATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Pirrolidinas / Proteínas Proto-Oncogênicas c-mdm2 / Anticorpos Monoclonais Humanizados / Para-Aminobenzoatos / Anticorpos Monoclonais / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Eur J Haematol Assunto da revista: HEMATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha