RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.

Hesbacher, Sonja; Pfitzer, Lisa; Wiedorfer, Katharina; Angermeyer, Sabrina; Borst, Andreas; Haferkamp, Sebastian; Scholz, Claus-Jürgen; Wobser, Marion; Schrama, David; Houben, Roland

Hesbacher, Sonja; Pfitzer, Lisa; Wiedorfer, Katharina; Angermeyer, Sabrina; Borst, Andreas; Haferkamp, Sebastian; Scholz, Claus-Jürgen; Wobser, Marion; Schrama, David; Houben, Roland.

Afiliação

Hesbacher S; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Pfitzer L; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Wiedorfer K; Department of Pharmacy, Center for Drug Research, University of Munich (Ludwigs-Maximilians-Universität), Munich, Germany.
Angermeyer S; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Borst A; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Haferkamp S; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Scholz CJ; Department of Dermatology, University of Regensburg, Regensburg, Germany.
Wobser M; Core Unit Systems Medicine, University of Würzburg, Würzburg, Germany.
Schrama D; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Houben R; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Oncotarget ; 7(22): 32956-68, 2016 May 31.

Article em En | MEDLINE | ID: mdl-27121059

Assuntos

Antígenos Virais de Tumores/metabolismo; Carcinoma de Célula de Merkel/metabolismo; Proteínas de Ligação a Retinoblastoma/metabolismo; Neoplasias Cutâneas/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Antígenos Virais de Tumores/genética; Carcinoma de Célula de Merkel/genética; Carcinoma de Célula de Merkel/patologia; Carcinoma de Célula de Merkel/virologia; Humanos; Poliomavírus das Células de Merkel/metabolismo; Infecções por Polyomavirus/genética; Infecções por Polyomavirus/metabolismo; Proteínas de Ligação a Retinoblastoma/genética; Neoplasias Cutâneas/genética; Neoplasias Cutâneas/patologia; Neoplasias Cutâneas/virologia; Transfecção; Ubiquitina-Proteína Ligases/genética

Palavras-chave

Large T antigen; Merkel cell carcinoma; polyomavirus; retinoblastoma protein; viral carcinogenesis

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Pele Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Célula de Merkel / Ubiquitina-Proteína Ligases / Proteínas de Ligação a Retinoblastoma / Antígenos Virais de Tumores Limite: Humans Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha

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