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POLE proofreading mutation, immune response and prognosis in endometrial cancer.
van Gool, Inge C; Bosse, Tjalling; Church, David N.
Afiliação
  • van Gool IC; Department of Pathology, Leiden University Medical Center , Leiden, the Netherlands.
  • Bosse T; Department of Pathology, Leiden University Medical Center , Leiden, the Netherlands.
  • Church DN; Molecular and Population Genetics Laboratory, The Wellcome Trust Centre for Human Genetics, University of Oxford , Oxford, UK.
Oncoimmunology ; 5(3): e1072675, 2016 Mar.
Article em En | MEDLINE | ID: mdl-27141333
ABSTRACT
Endometrial cancers (ECs) with POLE proofreading mutations are typified by ultramutation and excellent prognosis. We investigated whether these were related, and found that POLE-mutant ECs display a robust T cell response that corresponds to an enrichment of antigenic tumor neopeptides. Enhanced immunogenicity may explain the favorable outcome of POLE-mutant ECs.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Oncoimmunology Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Oncoimmunology Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Holanda