XPA: A key scaffold for human nucleotide excision repair.

Sugitani, Norie; Sivley, Robert M; Perry, Kelly E; Capra, John A; Chazin, Walter J

Sugitani, Norie; Sivley, Robert M; Perry, Kelly E; Capra, John A; Chazin, Walter J.

Afiliação

Sugitani N; Departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, and Computer Science, and Vanderbilt Genetics Institute and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232-7917, United States.
Sivley RM; Departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, and Computer Science, and Vanderbilt Genetics Institute and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232-7917, United States.
Perry KE; Departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, and Computer Science, and Vanderbilt Genetics Institute and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232-7917, United States.
Capra JA; Departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, and Computer Science, and Vanderbilt Genetics Institute and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232-7917, United States.
Chazin WJ; Departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, and Computer Science, and Vanderbilt Genetics Institute and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232-7917, United States. Electronic address: Walter.Chazin@vanderbilt.edu.

DNA Repair (Amst) ; 44: 123-135, 2016 08.

Article em En | MEDLINE | ID: mdl-27247238

ABSTRACT

ABSTRACT

Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.

Assuntos

Reparo do DNA; DNA/metabolismo; Proteína de Xeroderma Pigmentoso Grupo A/metabolismo; Xeroderma Pigmentoso/genética; Sequência de Aminoácidos; Animais; DNA/química; Dano ao DNA; Humanos; Modelos Moleculares; Mutação; Ligação Proteica; Domínios Proteicos; Mapeamento de Interação de Proteínas; Estrutura Secundária de Proteína; Índice de Gravidade de Doença; Xeroderma Pigmentoso/metabolismo; Xeroderma Pigmentoso/patologia; Proteína de Xeroderma Pigmentoso Grupo A/química; Proteína de Xeroderma Pigmentoso Grupo A/genética

Palavras-chave

DNA repair; NER; XPA; Xeroderma pigmentosum.

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Xeroderma Pigmentoso / DNA / Reparo do DNA / Proteína de Xeroderma Pigmentoso Grupo A Limite: Animals / Humans Idioma: En Revista: DNA Repair (Amst) Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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