Paradigm Shift in the Management Strategy for Epithelial Ovarian Cancer.
Am Soc Clin Oncol Educ Book
; 35: e247-57, 2016.
Article
em En
| MEDLINE
| ID: mdl-27249730
ABSTRACT
The hypothesis on the pathogenesis of epithelial ovarian cancer continues to evolve. Although epithelial ovarian cancer had been assumed to arise from the coelomic epithelium of the ovarian surface, it is now becoming clearer that the majority of serous carcinomas arise from epithelium of the distal fallopian tube, whereas clear cell and endometrioid cancers arise from endometriosis. Molecular and genomic characteristics of epithelial ovarian cancer have been extensively investigated. Our understanding of pathogenesis of the various histologic types of ovarian cancer have begun to inform changes to the strategies for management of epithelial ovarian cancer, which represent a paradigm shift not only for treatment but also for prevention, which previously had not been considered achievable. In this article, we will discuss novel attempts at the prevention of high-grade serous ovarian cancer and treatment strategies for two distinct entities in epithelial ovarian cancer low-grade serous and clear cell ovarian carcinomas, which are relatively rare and resistant to conventional chemotherapy.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
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Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
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Ovário
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Neoplasias Epiteliais e Glandulares
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Gerenciamento Clínico
Limite:
Female
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Humans
Idioma:
En
Revista:
Am Soc Clin Oncol Educ Book
Ano de publicação:
2016
Tipo de documento:
Article