A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer.
Mol Cell Oncol
; 3(1): e1035477, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-27308552
ABSTRACT
Pancreatic ductal adenocarcinoma originates from acinar cells that undergo acinar-to-ductal metaplasia (ADM). ADM is initiated in response to growth factors, inflammation, and oncogene activation and leads to a de-differentiated, duct-like phenotype. Our recent publication demonstrated a transforming growth factor α-Kras(G12D)-protein kinase D1-Notch1 signaling axis driving the induction of ADM and further progression to pancreatic intraepithelial neoplasia. This suggests that protein kinase D1 might be an early marker for tumor development and a potential target for drug development.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Mol Cell Oncol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos