Aberrant DR5 transport through disruption of lysosomal function suggests a novel mechanism for receptor activation.

Akpinar, Birce; Safarikova, Barbora; Laukova, Jarmila; Debnath, Shubhranshu; Vaculova, Alena Hyrslova; Zhivotovsky, Boris; Olsson, Magnus

Akpinar, Birce; Safarikova, Barbora; Laukova, Jarmila; Debnath, Shubhranshu; Vaculova, Alena Hyrslova; Zhivotovsky, Boris; Olsson, Magnus.

Afiliação

Akpinar B; Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Safarikova B; Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic.
Laukova J; Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic.
Debnath S; Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Vaculova AH; Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Brno, Czech Republic.
Zhivotovsky B; Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Olsson M; Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Oncotarget ; 7(36): 58286-58301, 2016 Sep 06.

Article em En | MEDLINE | ID: mdl-27506940

Assuntos

Autofagia; Lisossomos/metabolismo; Receptores do Ligante Indutor de Apoptose Relacionado a TNF/metabolismo; Antimetabólitos Antineoplásicos/farmacologia; Apoptose; Membrana Celular/metabolismo; Cloroquina/química; Colesterol/química; Fluoruracila/química; Células HCT116; Humanos; Ligantes; Macrolídeos/química; Mitocôndrias/metabolismo; Fagossomos; Transporte Proteico; Interferência de RNA; Transdução de Sinais/efeitos dos fármacos; Ligante Indutor de Apoptose Relacionado a TNF/farmacologia; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

DR5; apoptosis; autophagy; chloroquine; lysosomes

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Autofagia / Receptores do Ligante Indutor de Apoptose Relacionado a TNF / Lisossomos Limite: Humans Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Suécia

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