Cell autonomous or systemic EGFR blockade alters the immune-environment in squamous cell carcinomas.

Mascia, Francesca; Schloemann, Derek T; Cataisson, Christophe; McKinnon, Katherine M; Krymskaya, Ludmila; Wolcott, Karen M; Yuspa, Stuart H

Mascia, Francesca; Schloemann, Derek T; Cataisson, Christophe; McKinnon, Katherine M; Krymskaya, Ludmila; Wolcott, Karen M; Yuspa, Stuart H.

Afiliação

Mascia F; Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD.
Schloemann DT; Laboratory of Applied Biochemistry, Division of Biotechnology Research and Review III, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, FDA, White Oak, Silver Spring, MD.
Cataisson C; Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD.
McKinnon KM; Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD.
Krymskaya L; FACS Core Facility, Vaccine Branch, National Cancer Institute, NIH, Bethesda, MD.
Wolcott KM; FACS Core Facility, Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD.
Yuspa SH; FACS Core Facility, Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD.

Int J Cancer ; 139(11): 2593-7, 2016 12 01.

Article em En | MEDLINE | ID: mdl-27509256

Assuntos

Carcinoma de Células Escamosas/enzimologia; Carcinoma de Células Escamosas/imunologia; Receptores ErbB/antagonistas & inibidores; Neoplasias Cutâneas/enzimologia; Neoplasias Cutâneas/imunologia; Animais; Carcinoma de Células Escamosas/tratamento farmacológico; Carcinoma de Células Escamosas/genética; Receptores ErbB/genética; Receptores ErbB/imunologia; Gefitinibe; Imunocompetência; Queratinócitos/efeitos dos fármacos; Queratinócitos/enzimologia; Queratinócitos/imunologia; Camundongos; Inibidores de Proteínas Quinases/farmacologia; Quinazolinas/farmacologia; Neoplasias Cutâneas/tratamento farmacológico; Neoplasias Cutâneas/genética

Palavras-chave

EGFR; SCC; T regulatory cells; gefitinib; tumor immune-environment

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Pele Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Células Escamosas / Receptores ErbB Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Cancer Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Moldávia

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