Protective role of ACE2-Ang-(1-7)-Mas in myocardial fibrosis by downregulating K<sub>Ca</sub>3.1 channel via ERK1/2 pathway.

Wang, Li-Ping; Fan, Su-Jing; Li, Shu-Min; Wang, Xiao-Jun; Gao, Jun-Ling; Yang, Xiu-Hong

Protective role of ACE2-Ang-(1-7)-Mas in myocardial fibrosis by downregulating K_Ca3.1 channel via ERK1/2 pathway.

Wang, Li-Ping; Fan, Su-Jing; Li, Shu-Min; Wang, Xiao-Jun; Gao, Jun-Ling; Yang, Xiu-Hong.

Afiliação

Wang LP; Department of Physiology, School of Basic Medical Science, North China University of Science and Technology, No. 57, Jianshe South Road, Tangshan, Hebei, 063000, China. mywlpzjm@163.com.
Fan SJ; Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, North China University of Science and Technology, No. 57, Jianshe South Road, Tangshan, Hebei, 063000, China. mywlpzjm@163.com.
Li SM; Department of Physiology, School of Basic Medical Science, North China University of Science and Technology, No. 57, Jianshe South Road, Tangshan, Hebei, 063000, China.
Wang XJ; Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, North China University of Science and Technology, No. 57, Jianshe South Road, Tangshan, Hebei, 063000, China.
Gao JL; Department of Physiology, School of Basic Medical Science, North China University of Science and Technology, No. 57, Jianshe South Road, Tangshan, Hebei, 063000, China.
Yang XH; Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, North China University of Science and Technology, No. 57, Jianshe South Road, Tangshan, Hebei, 063000, China.

Pflugers Arch ; 468(11-12): 2041-2051, 2016 11.

Article em En | MEDLINE | ID: mdl-27592222

Assuntos

Angiotensina II/farmacologia; Cardiomiopatias/metabolismo; Canais de Potássio Ativados por Cálcio de Condutância Intermediária/metabolismo; Miocárdio/metabolismo; Peptidil Dipeptidase A/metabolismo; Angiotensina II/análogos & derivados; Enzima de Conversão de Angiotensina 2; Animais; Pressão Sanguínea; Cardiomiopatias/patologia; Diminazena/análogos & derivados; Diminazena/farmacologia; Fibrose; Canais de Potássio Ativados por Cálcio de Condutância Intermediária/genética; Sistema de Sinalização das MAP Quinases; Masculino; Camundongos; Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Proteína Quinase 3 Ativada por Mitógeno/metabolismo; Miocárdio/patologia; Miofibroblastos/efeitos dos fármacos; Miofibroblastos/metabolismo; Miofibroblastos/patologia; Peptidil Dipeptidase A/genética; Proto-Oncogene Mas; Proteínas Proto-Oncogênicas/metabolismo; Receptores Acoplados a Proteínas G/metabolismo

Palavras-chave

ACE2-Ang-(17)-Mas; ERK1/2 pathway; Intermediate-conductance Ca2+-activated K+ channel; Myocardial fibrosis

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Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Angiotensina II / Peptidil Dipeptidase A / Canais de Potássio Ativados por Cálcio de Condutância Intermediária / Cardiomiopatias / Miocárdio Limite: Animals Idioma: En Revista: Pflugers Arch Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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