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Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study.
French, Jacqueline A; Lawson, John A; Yapici, Zuhal; Ikeda, Hiroko; Polster, Tilman; Nabbout, Rima; Curatolo, Paolo; de Vries, Petrus J; Dlugos, Dennis J; Berkowitz, Noah; Voi, Maurizio; Peyrard, Severine; Pelov, Diana; Franz, David N.
Afiliação
  • French JA; NYU Comprehensive Epilepsy Center, New York, NY, USA. Electronic address: jacqueline.french@nyumc.org.
  • Lawson JA; Tuberous Sclerosis Multidisciplinary Management Clinic, Sydney Children's Hospital, Randwick, NSW, Australia.
  • Yapici Z; Division of Child Neurology, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Ikeda H; NHO Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.
  • Polster T; Paediatric Epileptology, Mara Hospital, Bethel Epilepsy Center, Germany.
  • Nabbout R; Hospital Necker-Enfants Malades, Paris Descartes University, Paris, France.
  • Curatolo P; Tor Vergata University Hospital, Rome, Italy.
  • de Vries PJ; Division of Child and Adolescent Psychiatry, University of Cape Town, Cape Town, South Africa.
  • Dlugos DJ; Departments of Neurology and Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Berkowitz N; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
  • Voi M; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
  • Peyrard S; Novartis Pharmaceuticals SAS, Rueil-Malmaison, France.
  • Pelov D; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
  • Franz DN; Departments of Pediatrics and Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Lancet ; 388(10056): 2153-2163, 2016 10 29.
Article em En | MEDLINE | ID: mdl-27613521
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Prevencao_e_fatores_de_risco / Agentes_cancerigenos / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Convulsões / Esclerose Tuberosa / Everolimo / Anticonvulsivantes / Antineoplásicos Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Prevencao_e_fatores_de_risco / Agentes_cancerigenos / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Convulsões / Esclerose Tuberosa / Everolimo / Anticonvulsivantes / Antineoplásicos Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Ano de publicação: 2016 Tipo de documento: Article