Synthesis and Evaluation of Tetraarylethylene-based Mono-, Bis-, and Tris(pyridinium) Derivatives for Image-Guided Mitochondria-Specific Targeting and Cytotoxicity of Metastatic Melanoma Cells.

Reedy, Jessica L; Hedlund, Devin K; Gabr, Moustafa T; Henning, Grant M; Pigge, F Christopher; Schultz, Michael K

Reedy, Jessica L; Hedlund, Devin K; Gabr, Moustafa T; Henning, Grant M; Pigge, F Christopher; Schultz, Michael K.

Afiliação

Reedy JL; Departments of Radiology and Radiation Oncology, Free Radical and Radiation Biology Program and Department of Chemistry, The University of Iowa , Iowa City, Iowa 52242, United States.
Hedlund DK; Departments of Radiology and Radiation Oncology, Free Radical and Radiation Biology Program and Department of Chemistry, The University of Iowa , Iowa City, Iowa 52242, United States.
Gabr MT; Departments of Radiology and Radiation Oncology, Free Radical and Radiation Biology Program and Department of Chemistry, The University of Iowa , Iowa City, Iowa 52242, United States.
Henning GM; Departments of Radiology and Radiation Oncology, Free Radical and Radiation Biology Program and Department of Chemistry, The University of Iowa , Iowa City, Iowa 52242, United States.
Pigge FC; Departments of Radiology and Radiation Oncology, Free Radical and Radiation Biology Program and Department of Chemistry, The University of Iowa , Iowa City, Iowa 52242, United States.
Schultz MK; Departments of Radiology and Radiation Oncology, Free Radical and Radiation Biology Program and Department of Chemistry, The University of Iowa , Iowa City, Iowa 52242, United States.

Bioconjug Chem ; 27(10): 2424-2430, 2016 Oct 19.

Article em En | MEDLINE | ID: mdl-27643916

Assuntos

Antineoplásicos/farmacologia; Melanoma/diagnóstico por imagem; Melanoma/tratamento farmacológico; Compostos de Piridínio/química; Compostos de Piridínio/farmacologia; Trifosfato de Adenosina/metabolismo; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Técnicas de Química Sintética; Ensaios de Seleção de Medicamentos Antitumorais/métodos; Fibroblastos/efeitos dos fármacos; Humanos; Melanoma/patologia; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Microscopia Confocal; Microscopia de Fluorescência; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Compostos de Piridínio/síntese química

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Pele Base de dados: MEDLINE Assunto principal: Compostos de Piridínio / Melanoma / Antineoplásicos Limite: Humans Idioma: En Revista: Bioconjug Chem Assunto da revista: BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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