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Secretome derived from breast tumor cell lines alters the morphology of human umbilical vein endothelial cells.
Gómez, Erika Olivia; Chirino, Yolanda Irasema; Delgado-Buenrostro, Norma Laura; López-Saavedra, Alejandro; Meraz-Cruz, Noemí; López-Marure, Rebeca.
Afiliação
  • Gómez EO; a Universidad Autónoma de la Ciudad de México, Colegio de Ciencias y Humanidades , Plantel San Lorenzo Tezonco , México.
  • Chirino YI; b Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, UNAM , México.
  • Delgado-Buenrostro NL; b Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, UNAM , México.
  • López-Saavedra A; c Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología , México.
  • Meraz-Cruz N; d Facultad de Medicina, UNAM , México.
  • López-Marure R; e Departamento de Fisiología (Biología Celular) , Instituto Nacional de Cardiología "Ignacio Chávez" , México.
Mol Membr Biol ; 33(1-2): 29-37, 2016 03.
Article em En | MEDLINE | ID: mdl-27690154
Metastases, responsible for most of the solid tumor associated deaths, require angiogenesis and changes in endothelial cells. In this work, the effect of the secretomes of three breast tumor cell lines (MCF-7, MDA-MB-231 and ZR-75-30) on human umbilical vein endothelial cells (HUVEC) morphology was investigated. HUVEC treated with secretomes from breast cells were analyzed by confocal and time-lapse microscopy. Secretomes from ZR-75-30 and MDA-MB-231 cells modify the morphology and adhesion of HUVEC. These changes may provoke the loss of endothelial monolayer integrity. In consequence, tumor cells could have an increased access to circulation, which would then enhance metastasis.
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Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Proteínas / Meios de Cultura / Células Endoteliais Limite: Female / Humans Idioma: En Revista: Mol Membr Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article
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Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Proteínas / Meios de Cultura / Células Endoteliais Limite: Female / Humans Idioma: En Revista: Mol Membr Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article