Secretome derived from breast tumor cell lines alters the morphology of human umbilical vein endothelial cells.
Mol Membr Biol
; 33(1-2): 29-37, 2016 03.
Article
em En
| MEDLINE
| ID: mdl-27690154
Metastases, responsible for most of the solid tumor associated deaths, require angiogenesis and changes in endothelial cells. In this work, the effect of the secretomes of three breast tumor cell lines (MCF-7, MDA-MB-231 and ZR-75-30) on human umbilical vein endothelial cells (HUVEC) morphology was investigated. HUVEC treated with secretomes from breast cells were analyzed by confocal and time-lapse microscopy. Secretomes from ZR-75-30 and MDA-MB-231 cells modify the morphology and adhesion of HUVEC. These changes may provoke the loss of endothelial monolayer integrity. In consequence, tumor cells could have an increased access to circulation, which would then enhance metastasis.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Meios de Cultura
/
Células Endoteliais
Limite:
Female
/
Humans
Idioma:
En
Revista:
Mol Membr Biol
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Ano de publicação:
2016
Tipo de documento:
Article