Measurement of fat content in vertebral marrow using a modified dixon sequence to differentiate benign from malignant processes.
J Magn Reson Imaging
; 45(5): 1534-1544, 2017 05.
Article
em En
| MEDLINE
| ID: mdl-27690264
ABSTRACT
PURPOSE:
To determine whether fat-signal-fraction (FF) map using a modified Dixon sequence could help differentiate benign from malignant bone lesions. MATERIALS ANDMETHODS:
Spine magnetic resonance images (MRIs) of 120 consecutive patients were studied by using a 3T MRI with standard T1 -weighted image (T1 WI) and modified-Dixon sequence for FF measurement. There were three groups a control group (n = 51) with normal vertebrae; a benign group (n = 40) with focal red marrow deposition, Schmorl's nodes, benign compression fracture, or Modic type 1 endplate degeneration; a malignant group (n = 29) with spinal malignancies. The following three parameters were measured on T1 WI and FF map by two radiologists independently T1 signal intensity (SI), FF and T1 SI of normal disc (SI). Then, Lesion-to-disc ratio (LDR = SI of the lesion/SId ) and FF ratio of lesion and normal marrow were calculated. The mean values of the parameters were compared among the groups and Receiver Operating Characteristic (ROC) curves were analyzed. Then a logistic regression was performed.RESULTS:
The FF (2.8%) and FF ratio (0.082) of malignancy were lower than benign lesions (P < 0.001). There was no difference in the LDR between malignancy and Schmorl's nodes (P = 0.795) or a benign compression fracture (P = 0.866). The areas under the ROC curves of FF and FF ratio were 93% and 87%, respectively, which were higher than those of the other parameters used for differentiation (P < 0.001). In logistic regression analyses, FF remained a significant variable that could be used to independently differentiate benign from malignant lesions, with an odds ratio of 1.9 (P < 0.001).CONCLUSION:
The FF and FF ratio obtained from FF maps using modified-Dixon sequence could be used to distinguish between benign and malignant causes of focal bone marrow abnormalities when difficulty in the qualitative interpretation of conventional MR images arises. LEVEL OF EVIDENCE 3 J. MAGN. RESON. IMAGING 2017;451534-1544.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Coluna Vertebral
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Medula Óssea
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Imageamento por Ressonância Magnética
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Fraturas da Coluna Vertebral
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Fraturas por Compressão
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Vértebras Lombares
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Qualitative_research
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Magn Reson Imaging
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2017
Tipo de documento:
Article