<i>PXR</i> variants: the impact on drug metabolism and therapeutic responses.

Brewer, C Trent; Chen, Taosheng

PXR variants: the impact on drug metabolism and therapeutic responses.

Brewer, C Trent; Chen, Taosheng.

Afiliação

Brewer CT; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Acta Pharm Sin B ; 6(5): 441-449, 2016 Sep.

Article em En | MEDLINE | ID: mdl-27709012

Palavras-chave

AF, activating function; BAMCA, bacterial artificial chromosome arraybased methylated CpG island amplification; CYP, cytochrome P450; Drug metabolism; GST, glutathione S-transferase; MDR, multidrug resistance protein; NHR, nuclear hormone receptor; P-gp, P-glycoprotein; PXR1, PXR transcript variant 1 (434 residues); PXR2, transcript variant 2 (473 residues); PXR3, transcript variant 3 (397 residues); PXR4, transcript variant 4 (322 residues;AK122990); Pregnane X receptor; RACE, 5' rapid amplification of cDNA ends; Therapeutic responses; Toxicity; Transcript variants; UGT, UDP-glucuronosyltransferase; UTR, untranslated region; shRNA, short hairpin RNA; siRNA, small interfering RNA

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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