Aldh, aldehyde dehydrogenase; Asbt, solute carrier family 10, member 2 (apical sodium/bile acid cotransporter); CAR; CAR, constitutive androstane receptor; CITCO, 6-(4-chlorophenyl)imidazo [2,1-b](1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; Cq, quantification cycle; Cyp, cytochrome P450; DPGs, drug-processing genes (genes that encodes drug metabolizing enzymes or transporters); Drug-metabolizing enzymes; Drug-processing genes; Gst, glutathione S-trasnferase; H3, Histone 3; HRP, horseradish peroxidase; Intestine; Mice; Mrp, multi-drug resistance-associated protein (ABC transporter family C member); Nqo1, NAD(P)H dehydrogenase quinone 1; Nrf2, nuclear factor erythroid 2-related factor 2; Oatp, organic anion transporting polypeptide (solute carrier organic anion transporter family member); PBS, phosphate-buffered saline; PBST, phosphate-buffered saline with 0.05% tween 20; PPARα, peroxisome proliferator activated receptor alpha; PVDF, polyvinylidene difluoride; Papss2, 3ʹ-phosphoadenosine 5ʹ-phosphosulfate synthase 2; ST buffer, sucrose Tris buffer; Sult, sulfotransferase; TCPOBOP, 3,3ʹ,5,5ʹ-tetrachloro-1,4-bis(pyridyloxy)benzene; Transporters; Ugt, UDP glucuronosyltransferase; WT, wild-type; cDNA, complementary DNA; ddCq, delta delta Cq; hCAR, human constitutive androstane receptor; qPCR, quantitative polymerase chain reaction