New 2-Aminothiazoline derivatives lower blood pressure of spontaneously hypertensive rats (SHR) via I<sub>1</sub>-imidazoline and alpha-2 adrenergic receptors activation.

Ferreira, Renan B; de Oliveira, Mariana G; Antunes, Edson; Almeida, Wanda P; Ibrahim, Badr M; Abdel-Rahman, Abdel A

New 2-Aminothiazoline derivatives lower blood pressure of spontaneously hypertensive rats (SHR) via I₁-imidazoline and alpha-2 adrenergic receptors activation.

Ferreira, Renan B; de Oliveira, Mariana G; Antunes, Edson; Almeida, Wanda P; Ibrahim, Badr M; Abdel-Rahman, Abdel A.

Afiliação

Ferreira RB; Institute of Chemistry, University of Campinas, PO Box 6194, ZC 13083-970 Campinas, SP, Brazil.
de Oliveira MG; Department of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
Antunes E; Department of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
Almeida WP; Faculty of Pharmaceutical Sciences, University of Campinas, PO Box 6029, ZC 13083-859 Campinas, SP, Brazil. Electronic address: wanda.almeida@fcf.unicamp.br.
Ibrahim BM; Department of Pharmacology and Toxicology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Abdel-Rahman AA; Department of Pharmacology and Toxicology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.

Eur J Pharmacol ; 791: 803-810, 2016 Nov 15.

Article em En | MEDLINE | ID: mdl-27729248

Assuntos

Anti-Hipertensivos/química; Anti-Hipertensivos/farmacologia; Pressão Sanguínea/efeitos dos fármacos; Receptores de Imidazolinas/metabolismo; Receptores Adrenérgicos alfa 2/metabolismo; Tiazóis/química; Tiazóis/farmacologia; Animais; Benzofuranos/farmacologia; Imidazóis/farmacologia; Modelos Moleculares; Conformação Molecular; Células PC12; Ratos; Ratos Endogâmicos SHR

Palavras-chave

Aminothiazoline; Binding assay; Hypertension; Imidazoline receptor; PC12 cells

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Tiazóis / Pressão Sanguínea / Receptores Adrenérgicos alfa 2 / Receptores de Imidazolinas / Anti-Hipertensivos Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil

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