Detection and Quantification of KIT Mutations in ctDNA by Plasma Safe-SeqS.
Adv Exp Med Biol
; 924: 187-189, 2016.
Article
em En
| MEDLINE
| ID: mdl-27753042
ABSTRACT
We have designed a highly sensitive assay based on the Safe-SeqS technology to detect de novo mutations in the KIT gene and tested its performance. This assay was applied to plasma samples of GIST patients before and after treatment with regorafenib (GRID III trial) and mutations at known and novel sites of potential secondary resistance were identified.
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Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Análise Mutacional de DNA
/
Proteínas Proto-Oncogênicas c-kit
/
Mutação
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha