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Cytoreductive Nephrectomy in the Tyrosine Kinase Inhibitor Era: A Question That May Never Be Answered.
Stewart, Grant D; Aitchison, Michael; Bex, Axel; Larkin, James; Lawless, Claire; Méjean, Arnaud; Nathan, Paul; Oades, Grenville; Patard, Jean-Jacques; Paul, James; Ravaud, Alain; Escudier, Bernard.
Afiliação
  • Stewart GD; Academic Urology Group, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. Electronic address: gds35@cam.ac.uk.
  • Aitchison M; Royal Free Hospital, London, UK.
  • Bex A; Netherlands Cancer Institute, Amsterdam, Netherlands.
  • Larkin J; Royal Marsden Hospital, London, UK.
  • Lawless C; CRUK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, UK.
  • Méjean A; Université Paris Descartes, Paris, France.
  • Nathan P; Mount Vernon Hospital, Northwood, UK.
  • Oades G; Queen Elizabeth University Hospital, Glasgow, UK.
  • Patard JJ; Hôpital Bicetre, Paris, France.
  • Paul J; CRUK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, UK.
  • Ravaud A; CHU Bordeaux, Bordeaux, France.
  • Escudier B; Gustave Roussy Institute, Paris, France.
Eur Urol ; 71(6): 845-847, 2017 06.
Article em En | MEDLINE | ID: mdl-27815086
Despite great interest, two randomised controlled trials (RCTs) of cytoreductive nephrectomy in the tyrosine kinase inhibitor setting in metastatic renal cell carcinoma have either closed early (SURTIME) or are recruiting very slowly (CARMENA) after 7 yr. Challenges in RCT delivery in uro-oncologic surgery are many. Multiple steps are needed to ensure strong recruitment to trials addressing important urologic cancer questions. Feasibility/pilot studies are key stepping stones towards successful delivery of surgical RCTs.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Inibidores de Proteínas Quinases / Procedimentos Cirúrgicos de Citorredução / Neoplasias Renais / Nefrectomia / Antineoplásicos Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Eur Urol Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Inibidores de Proteínas Quinases / Procedimentos Cirúrgicos de Citorredução / Neoplasias Renais / Nefrectomia / Antineoplásicos Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Eur Urol Ano de publicação: 2017 Tipo de documento: Article