Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge.

Wepler, Martin; Beloiartsev, Arkadi; Buswell, Mary D; Panigrahy, Dipak; Malhotra, Rajeev; Buys, Emmanuel S; Radermacher, Peter; Ichinose, Fumito; Bloch, Donald B; Zapol, Warren M

Wepler, Martin; Beloiartsev, Arkadi; Buswell, Mary D; Panigrahy, Dipak; Malhotra, Rajeev; Buys, Emmanuel S; Radermacher, Peter; Ichinose, Fumito; Bloch, Donald B; Zapol, Warren M.

Afiliação

Wepler M; Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Beloiartsev A; Harvard Medical School, Boston, Massachusetts.
Buswell MD; Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Panigrahy D; Harvard Medical School, Boston, Massachusetts.
Malhotra R; Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Buys ES; Harvard Medical School, Boston, Massachusetts.
Radermacher P; Harvard Medical School, Boston, Massachusetts.
Ichinose F; Center for Vascular Biology Research and Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Bloch DB; Harvard Medical School, Boston, Massachusetts.
Zapol WM; Cardiology Division and Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Am J Physiol Lung Cell Mol Physiol ; 311(6): L1213-L1221, 2016 Dec 01.

Article em En | MEDLINE | ID: mdl-27815261

Assuntos

Epóxido Hidrolases/antagonistas & inibidores; Epóxido Hidrolases/deficiência; Hipóxia/enzimologia; Hipóxia/fisiopatologia; Artéria Pulmonar/enzimologia; Artéria Pulmonar/fisiopatologia; Vasoconstrição; Animais; Ácido Araquidônico/metabolismo; Gasometria; Citocinas/genética; Citocinas/metabolismo; Epóxido Hidrolases/metabolismo; Hemodinâmica; Hipóxia/complicações; Lipopolissacarídeos; Pulmão/metabolismo; Pulmão/patologia; Masculino; Camundongos Endogâmicos C57BL; Oxigênio/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Solubilidade

Palavras-chave

endotoxemia; hypoxic pulmonary vasoconstriction; knockout and inhibition; mice; soluble epoxide hydrolase

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Artéria Pulmonar / Vasoconstrição / Epóxido Hidrolases / Hipóxia Limite: Animals Idioma: En Revista: Am J Physiol Lung Cell Mol Physiol Assunto da revista: BIOLOGIA MOLECULAR / FISIOLOGIA Ano de publicação: 2016 Tipo de documento: Article

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