Dietary Fructose-Induced Hepatic Injury in Male and Female Rats: Influence of Resveratrol.
Drug Res (Stuttg)
; 67(2): 103-110, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27824430
ABSTRACT
Purpose:
Relatively little is known about gender-dependent susceptibility to hepatic injury induced by nutritional factors. In the current study, we investigated dietary fructose-induced hepatic degeneration and roles of endothelial nitric oxide synthase (eNOS), insulin receptor (IRß) and substrate-1 (IRS-1) expressions in association with inflammatory markers in male and female rats. Moreover, we examined potential effect of resveratrol on fructose-induced changes.Methods:
Male and female rats were divided into 4 groups as control, resveratrol, fructose and resveratrol plus fructose. All rats were fed with a standard diet with or without resveratrol (500 mg/kg). Fructose was given as 10% in drinking waterfor 24 weeks.Results:
Long-term dietary fructose caused parenchymal degeneration and hyperemia in association with impaired eNOS mRNA/protein expressions in liver of male and female rats. This dietary intervention also led to increases in hepatic triglyceride content, TNFα and IL-1ß levels in both genders. Gender-related differences to consequence of fructose consumption were not obvious. Resveratrol supplementation markedly attenuated hepatic degeneration, hyperemia and triglyceride content in association with reduced TNFα and IL-1ß levels, but enhanced IRß mRNA and IRS-1 protein, in male and female rats upon fructose feeding.Conclusion:
Long-term dietary fructose causes hepatic degeneration possibly via a decrease in eNOS, but increase in TNFα and IL-1ß, in both genders. Resveratrol supplementation improved fructose-induced hepatic injury.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
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Óxido Nítrico Sintase Tipo III
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Hepatopatia Gordurosa não Alcoólica
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Dieta da Carga de Carboidratos
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Frutose
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Fígado
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Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Drug Res (Stuttg)
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Turquia