Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus.

Zhang, Yan; Yu, Xiao-Jing; Chen, Wen-Sheng; Gao, Hong-Li; Liu, Kai-Li; Shi, Xiao-Lian; Fan, Xiao-Yan; Jia, Lin-Lin; Cui, Wei; Zhu, Guo-Qing; Liu, Jin-Jun; Kang, Yu-Ming

Zhang, Yan; Yu, Xiao-Jing; Chen, Wen-Sheng; Gao, Hong-Li; Liu, Kai-Li; Shi, Xiao-Lian; Fan, Xiao-Yan; Jia, Lin-Lin; Cui, Wei; Zhu, Guo-Qing; Liu, Jin-Jun; Kang, Yu-Ming.

Afiliação

Zhang Y; Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, 710061, China.
Yu XJ; Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, 710061, China.
Chen WS; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Gao HL; Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, 710061, China.
Liu KL; Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, 710061, China.
Shi XL; Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Fan XY; Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, 710061, China.
Jia LL; Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, 710061, China.
Cui W; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Zhu GQ; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing, 210029, China.
Liu JJ; Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, 710061, China.
Kang YM; Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, 710061, China.

Sci Rep ; 6: 37467, 2016 11 24.

Article em En | MEDLINE | ID: mdl-27881877

Assuntos

Maleato de Dizocilpina/farmacologia; Hipertensão Renovascular/tratamento farmacológico; Losartan/farmacologia; Condicionamento Físico Animal; Espécies Reativas de Oxigênio/antagonistas & inibidores; Sistema Renina-Angiotensina/efeitos dos fármacos; Bloqueadores do Receptor Tipo 1 de Angiotensina II/farmacologia; Animais; Modelos Animais de Doenças; Antagonistas de Aminoácidos Excitatórios/farmacologia; Regulação da Expressão Gênica; Ácido Glutâmico/metabolismo; Hipertensão Renovascular/genética; Hipertensão Renovascular/metabolismo; Hipertensão Renovascular/patologia; Masculino; NADPH Oxidase 2/genética; NADPH Oxidase 2/metabolismo; NADPH Oxidases/genética; NADPH Oxidases/metabolismo; Núcleo Hipotalâmico Paraventricular/efeitos dos fármacos; Núcleo Hipotalâmico Paraventricular/metabolismo; Núcleo Hipotalâmico Paraventricular/patologia; Peptidil Dipeptidase A/genética; Peptidil Dipeptidase A/metabolismo; Ratos; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo; Receptor Tipo 1 de Angiotensina/genética; Receptor Tipo 1 de Angiotensina/metabolismo; Receptores de Glutamato/genética; Receptores de Glutamato/metabolismo; Comportamento Sedentário; Transdução de Sinais; Superóxido Dismutase/genética; Superóxido Dismutase/metabolismo

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Condicionamento Físico Animal / Sistema Renina-Angiotensina / Maleato de Dizocilpina / Espécies Reativas de Oxigênio / Losartan / Hipertensão Renovascular Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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