miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions.

Cui, Huachun; Ge, Jing; Xie, Na; Banerjee, Sami; Zhou, Yong; Liu, Rui-Ming; Thannickal, Victor J; Liu, Gang

Cui, Huachun; Ge, Jing; Xie, Na; Banerjee, Sami; Zhou, Yong; Liu, Rui-Ming; Thannickal, Victor J; Liu, Gang.

Afiliação

Cui H; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and.
Ge J; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and.
Xie N; Department of Geriatrics and Institute of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Banerjee S; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and.
Zhou Y; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and.
Liu RM; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and.
Thannickal VJ; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and.
Liu G; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; and.

Am J Physiol Lung Cell Mol Physiol ; 312(3): L415-L424, 2017 Mar 01.

Article em En | MEDLINE | ID: mdl-27979858

Assuntos

Envelhecimento/genética; Envelhecimento/patologia; Células Epiteliais Alveolares/metabolismo; Células Epiteliais Alveolares/patologia; MicroRNAs/metabolismo; Animais; Apoptose/genética; Bleomicina; Linhagem Celular; Proliferação de Células; Senescência Celular; Fibroblastos/metabolismo; Fibroblastos/patologia; Humanos; Fibrose Pulmonar Idiopática/genética; Fibrose Pulmonar Idiopática/patologia; Fibrose Pulmonar Idiopática/prevenção & controle; Camundongos; MicroRNAs/genética; Mitocôndrias/metabolismo; Fenótipo; Regulação para Cima/genética

Palavras-chave

aging; alveolar epithelial cell; apoptosis; lung fibrosis; micro-RNA; senescence

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Envelhecimento / MicroRNAs / Células Epiteliais Alveolares Limite: Animals / Humans Idioma: En Revista: Am J Physiol Lung Cell Mol Physiol Assunto da revista: BIOLOGIA MOLECULAR / FISIOLOGIA Ano de publicação: 2017 Tipo de documento: Article

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