The effect of ethephon on immune system in male offspring of mice.
Environ Toxicol Pharmacol
; 49: 119-123, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-27987403
ABSTRACT
Ethephon can liberate ethylene which could interfere the plant growth process. The aim of the present study was to determine the effect of ethephon on developing immune system of male offspring. Ethephon could enhance NK cell activity in male mice. For 4-week-old male mice, lymphocytes of peripheral blood increased while the hemolytic plaque number decreased. Delayed type hypersensitivity(DTH) was inhibited in all groups. The expression of protein Bcl11b and p-p38 in thymus of treatment groups were lower than control group. Our results indicated that cellular immunity of male offspring is more sensitive to ethephon when exposed in pregnancy and lactation period. It should be emphasized that exposure to ethephon during the in utero stage and lactation stage still could damage the immune function of animal in the period before fully mature even in the dosage that could not influence the immune function of adult animal.
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Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
/
Reguladores de Crescimento de Plantas
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Efeitos Tardios da Exposição Pré-Natal
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Ano de publicação:
2017
Tipo de documento:
Article