An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice.

Hasib, Annie; Ng, Ming T; Gault, Victor A; Khan, Dawood; Parthsarathy, Vadivel; Flatt, Peter R; Irwin, Nigel

Hasib, Annie; Ng, Ming T; Gault, Victor A; Khan, Dawood; Parthsarathy, Vadivel; Flatt, Peter R; Irwin, Nigel.

Afiliação

Hasib A; SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK.
Ng MT; SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK.
Gault VA; SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK.
Khan D; SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK.
Parthsarathy V; SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK.
Flatt PR; SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK.
Irwin N; SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK. n.irwin@ulster.ac.uk.

Diabetologia ; 60(3): 541-552, 2017 03.

Article em En | MEDLINE | ID: mdl-28004148

Assuntos

Polipeptídeo Inibidor Gástrico/uso terapêutico; Neurotensina/uso terapêutico; Peptídeos/uso terapêutico; Animais; Glicemia/efeitos dos fármacos; Linhagem Celular; Diabetes Mellitus Tipo 2/tratamento farmacológico; Diabetes Mellitus Tipo 2/fisiopatologia; Dieta Hiperlipídica; Glucose/metabolismo; Homeostase/efeitos dos fármacos; Imuno-Histoquímica; Insulina/metabolismo; Células Secretoras de Insulina/efeitos dos fármacos; Células Secretoras de Insulina/metabolismo; Masculino; Camundongos; Fragmentos de Peptídeos/uso terapêutico

Palavras-chave

GIP; Glucose; Glucose homeostasis; Glucose-dependent insulinotropic polypeptide; High-fat feeding; Hybrid; Insulin secretion; Xenin

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Peptídeos / Neurotensina / Polipeptídeo Inibidor Gástrico Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Diabetologia Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido

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