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Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
Huang, Ying; Zhang, Jeff; Yu, Zhengtian; Zhang, Hailong; Wang, Youzhen; Lingel, Andreas; Qi, Wei; Gu, Justin; Zhao, Kehao; Shultz, Michael D; Wang, Long; Fu, Xingnian; Sun, Yongfeng; Zhang, Qiong; Jiang, Xiangqing; Zhang, Jiangwei; Zhang, Chunye; Li, Ling; Zeng, Jue; Feng, Lijian; Zhang, Chao; Liu, Yueqin; Zhang, Man; Zhang, Lijun; Zhao, Mengxi; Gao, Zhenting; Liu, Xianghui; Fang, Douglas; Guo, Haibing; Mi, Yuan; Gabriel, Tobias; Dillon, Michael P; Atadja, Peter; Oyang, Counde.
Afiliação
  • Huang Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhang J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Yu Z; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhang H; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Wang Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Lingel A; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Qi W; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Gu J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhao K; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Shultz MD; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Wang L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Fu X; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Sun Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhang Q; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Jiang X; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhang J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhang C; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Li L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zeng J; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Feng L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhang C; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Liu Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhang M; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhang L; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Zhao M; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Gao Z; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Liu X; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Fang D; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Guo H; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Mi Y; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Gabriel T; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Dillon MP; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Atadja P; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
  • Oyang C; Novartis Institutes for BioMedical Research , 4218 Jinke Road, Shanghai 201203, China.
J Med Chem ; 60(6): 2215-2226, 2017 03 23.
Article em En | MEDLINE | ID: mdl-28092155
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Sulfonas / Triazóis / Complexo Repressor Polycomb 2 / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Sulfonas / Triazóis / Complexo Repressor Polycomb 2 / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China