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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.
Turner, Kristen M; Deshpande, Viraj; Beyter, Doruk; Koga, Tomoyuki; Rusert, Jessica; Lee, Catherine; Li, Bin; Arden, Karen; Ren, Bing; Nathanson, David A; Kornblum, Harley I; Taylor, Michael D; Kaushal, Sharmeela; Cavenee, Webster K; Wechsler-Reya, Robert; Furnari, Frank B; Vandenberg, Scott R; Rao, P Nagesh; Wahl, Geoffrey M; Bafna, Vineet; Mischel, Paul S.
Afiliação
  • Turner KM; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA.
  • Deshpande V; Department of Computer Science and Engineering, University of California at San Diego, La Jolla, California 92093, USA.
  • Beyter D; Department of Computer Science and Engineering, University of California at San Diego, La Jolla, California 92093, USA.
  • Koga T; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA.
  • Rusert J; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
  • Lee C; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
  • Li B; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA.
  • Arden K; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA.
  • Ren B; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA.
  • Nathanson DA; Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California 90095, USA.
  • Kornblum HI; Department of Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, California 90095, USA.
  • Taylor MD; Neuropsychiatric Institute-Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry and Biobehavioral Sciences, David Geffen UCLA School of Medicine, Los Angeles, California 90095, USA.
  • Kaushal S; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Cavenee WK; Moores Cancer Center, University of California at San Diego, La Jolla, California 92093, USA.
  • Wechsler-Reya R; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA.
  • Furnari FB; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
  • Vandenberg SR; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA.
  • Rao PN; Department of Pathology, University of California San Francisco, San Francisco, California 94143, USA.
  • Wahl GM; Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, California 90095, USA.
  • Bafna V; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
  • Mischel PS; Department of Computer Science and Engineering, University of California at San Diego, La Jolla, California 92093, USA.
Nature ; 543(7643): 122-125, 2017 03 02.
Article em En | MEDLINE | ID: mdl-28178237
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Oncogenes / Amplificação de Genes / Heterogeneidade Genética / Evolução Molecular / Variações do Número de Cópias de DNA / Modelos Genéticos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Oncogenes / Amplificação de Genes / Heterogeneidade Genética / Evolução Molecular / Variações do Número de Cópias de DNA / Modelos Genéticos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos