Human Neural Progenitor Transplantation Rescues Behavior and Reduces &#945;-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.

Goldberg, Natalie R S; Marsh, Samuel E; Ochaba, Joseph; Shelley, Brandon C; Davtyan, Hayk; Thompson, Leslie M; Steffan, Joan S; Svendsen, Clive N; Blurton-Jones, Mathew

Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.

Goldberg, Natalie R S; Marsh, Samuel E; Ochaba, Joseph; Shelley, Brandon C; Davtyan, Hayk; Thompson, Leslie M; Steffan, Joan S; Svendsen, Clive N; Blurton-Jones, Mathew.

Afiliação

Goldberg NRS; Department of Neurobiology and Behavior, Irvine, California, USA.
Marsh SE; Sue and Bill Gross Stem Cell Research Center, Irvine, California, USA.
Ochaba J; Institute for Memory Impairments and Neurological Disorders, Irvine, California, USA.
Shelley BC; Department of Neurobiology and Behavior, Irvine, California, USA.
Davtyan H; Sue and Bill Gross Stem Cell Research Center, Irvine, California, USA.
Thompson LM; Institute for Memory Impairments and Neurological Disorders, Irvine, California, USA.
Steffan JS; Department of Neurobiology and Behavior, Irvine, California, USA.
Svendsen CN; Institute for Memory Impairments and Neurological Disorders, Irvine, California, USA.
Blurton-Jones M; Department of Biomedical Sciences, Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Stem Cells Transl Med ; 6(6): 1477-1490, 2017 06.

Article em En | MEDLINE | ID: mdl-28225193

Assuntos

Doença por Corpos de Lewy/terapia; Células-Tronco Neurais/transplante; Transplante de Células-Tronco/métodos; alfa-Sinucleína/metabolismo; Animais; Astrócitos/citologia; Astrócitos/metabolismo; Células Cultivadas; Humanos; Memória; Camundongos; Células-Tronco Neurais/citologia; Células-Tronco Neurais/metabolismo; Neurogênese

Palavras-chave

Astrocyte; Dopamine; Glial progenitor; Glutamate; Memory; Pathology; Synucleinopathy; Transplantation

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Doença por Corpos de Lewy / Transplante de Células-Tronco / Alfa-Sinucleína / Células-Tronco Neurais Limite: Animals / Humans Idioma: En Revista: Stem Cells Transl Med Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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