Synthesis and Antineoplastic Evaluation of Mitochondrial ComplexâII (Succinate Dehydrogenase) Inhibitors Derived from AtpeninâA5.

Wang, Hezhen; Huwaimel, Bader; Verma, Kshitij; Miller, James; Germain, Todd M; Kinarivala, Nihar; Pappas, Dimitri; Brookes, Paul S; Trippier, Paul C

Synthesis and Antineoplastic Evaluation of Mitochondrial ComplexâII (Succinate Dehydrogenase) Inhibitors Derived from AtpeninâA5.

Wang, Hezhen; Huwaimel, Bader; Verma, Kshitij; Miller, James; Germain, Todd M; Kinarivala, Nihar; Pappas, Dimitri; Brookes, Paul S; Trippier, Paul C.

Afiliação

Wang H; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX, 79106, USA.
Huwaimel B; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX, 79106, USA.
Verma K; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX, 79106, USA.
Miller J; Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Germain TM; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA.
Kinarivala N; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX, 79106, USA.
Pappas D; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA.
Brookes PS; Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Trippier PC; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX, 79106, USA.

ChemMedChem ; 12(13): 1033-1044, 2017 07 06.

Article em En | MEDLINE | ID: mdl-28523727

Assuntos

Antineoplásicos/farmacologia; Piridonas/farmacologia; Succinato Desidrogenase/antagonistas & inibidores; Animais; Antineoplásicos/síntese química; Antineoplásicos/química; Antineoplásicos/toxicidade; Benzamidas; Domínio Catalítico; Linhagem Celular Tumoral; Transporte de Elétrons; Etoposídeo/farmacologia; Células HEK293; Humanos; Camundongos; Modelos Moleculares; Nitrilas; Feniltioidantoína/análogos & derivados; Feniltioidantoína/farmacologia; Piridonas/síntese química; Piridonas/química; Piridonas/toxicidade; Relação Quantitativa Estrutura-Atividade; Suínos

Palavras-chave

anticancer agents; atpeninâA5; mitochondria; mitochondrial complexâII; succinate dehydrogenase

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Prevencao_e_fatores_de_risco / Agentes_cancerigenos Base de dados: MEDLINE Assunto principal: Piridonas / Succinato Desidrogenase / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: ChemMedChem Assunto da revista: FARMACOLOGIA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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