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Hepatic Disease with Portal Hypertension and Acute Juvenile Paracoccidioidomycosis: A Report of Two Cases and Literature Review.
de Macedo, Priscila Marques; Almeida-Paes, Rodrigo; Freitas, Dayvison Francis Saraiva; Brito-Santos, Fabio; Figueiredo-Carvalho, Maria Helena Galdino; de Almeida Soares, João Carlos; Freitas, Andrea D'Ávila; Zancopé-Oliveira, Rosely Maria; do Valle, Antonio Carlos Francesconi.
Afiliação
  • de Macedo PM; Infectious Dermatology Clinical Research Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil. priscila.marques@ini.fiocruz.br.
  • Almeida-Paes R; Laboratório de Pesquisa Clínica em Dermatologia Infecciosa, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Avenida Brasil, 4365, Manguinhos, Rio de Janeiro, 21045-900, Brazil. priscila.marques@ini.fiocruz.br.
  • Freitas DFS; Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
  • Brito-Santos F; Infectious Dermatology Clinical Research Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
  • Figueiredo-Carvalho MHG; Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
  • de Almeida Soares JC; Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
  • Freitas AD; Department of Gastroenterology, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
  • Zancopé-Oliveira RM; Department of Inpatient Health Care, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
  • do Valle ACF; Mycology Laboratory, Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro, Brazil.
Mycopathologia ; 182(9-10): 915-919, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28577123
Paracoccidioidomycosis (PCM) is a neglected systemic mycosis endemic to Latin America caused by dimorphic fungi of the genus Paracoccidioides. The acute juvenile PCM is a severe type of presentation that usually affects young vulnerable patients and rarely progresses to portal hypertension. Here, two cases of liver disease and portal hypertension as complications of acute juvenile PCM are reported. Diagnosis of PCM was performed by isolation of the fungus and molecular identification of the strains provided through partial sequencing of two protein encoding genes, arf and gp43. Genotypic analysis revealed that Paracoccidioides brasiliensis S1 was the phylogenic species involved in both cases. Patients presented a good clinical response to amphotericin B and sulfamethoxazole-trimethoprim. These results highlight the importance of the interdisciplinary approach in patients with severe forms of PCM to avoid and treat complications, and the necessity of further investigations focusing on host-pathogen interaction in order to explain the broad clinical spectrum in PCM as well as the severity and poor outcome in some clinical cases.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Paracoccidioides / Paracoccidioidomicose / Hipertensão Portal / Hepatopatias Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Mycopathologia Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Paracoccidioides / Paracoccidioidomicose / Hipertensão Portal / Hepatopatias Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Mycopathologia Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil