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Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study.
Altes, Talissa A; Meyer, Craig H; Mata, Jaime F; Froh, Deborah K; Paget-Brown, Alix; Gerald Teague, W; Fain, Sean B; de Lange, Eduard E; Ruppert, Kai; Botfield, Martyn C; Johnson, Mac A; Mugler, John P.
Afiliação
  • Altes TA; Department of Radiology, University of Missouri, Columbia, MO, United States; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States. Electronic address: altest@health.missouri.edu.
  • Meyer CH; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.
  • Mata JF; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
  • Froh DK; Department of Pediatrics, University of Virginia, Charlottesville, VA, United States.
  • Paget-Brown A; Department of Pediatrics, University of Virginia, Charlottesville, VA, United States.
  • Gerald Teague W; Department of Pediatrics, University of Virginia, Charlottesville, VA, United States.
  • Fain SB; Department of Medical Physics and Radiology, University of Wisconsin, Madison, WI, United States.
  • de Lange EE; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States.
  • Ruppert K; Department of Radiology University of Pennsylvania, Philadelphia, PA, United States.
  • Botfield MC; Vertex Pharmaceuticals Incorporated, Boston, MA, United States.
  • Johnson MA; Vertex Pharmaceuticals Incorporated, Boston, MA, United States.
  • Mugler JP; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.
Clin Imaging ; 45: 105-110, 2017.
Article em En | MEDLINE | ID: mdl-28646735
ABSTRACT

PURPOSE:

To develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. MATERIALS AND

METHODS:

HHe ventilation MRI was performed on seven children ≤4years old. Contiguous 2D-spiral helium-3 images were acquired sequentially with a scan time of ≤0.2s/slice.

RESULTS:

Motion-artifact-free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases.

CONCLUSION:

HHe ventilation MRI can aid assessment of pediatric lung disease even at a young age.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Estudo de Prova de Conceito / Hélio / Isótopos / Pulmão / Pneumopatias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Clin Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Estudo de Prova de Conceito / Hélio / Isótopos / Pulmão / Pneumopatias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Clin Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2017 Tipo de documento: Article