Di-(2-ethylhexyl) phthalate suppresses IL-12p40 production by GM-CSF-dependent macrophages via the PPAR&#945;/TNFAIP3/TRAF6 axis after lipopolysaccharide stimulation.

Yamaguchi, R; Sakamoto, A; Yamamoto, T; Narahara, S; Sugiuchi, H; Hisada, A; Katoh, T; Yamaguchi, Y

Di-(2-ethylhexyl) phthalate suppresses IL-12p40 production by GM-CSF-dependent macrophages via the PPARα/TNFAIP3/TRAF6 axis after lipopolysaccharide stimulation.

Yamaguchi, R; Sakamoto, A; Yamamoto, T; Narahara, S; Sugiuchi, H; Hisada, A; Katoh, T; Yamaguchi, Y.

Afiliação

Yamaguchi R; 1 Department of Public Health, Faculty of Life Sciences, Kumamoto University School of Medicine, Kumamoto, Japan.
Sakamoto A; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Yamamoto T; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Narahara S; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Sugiuchi H; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Hisada A; 2 Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan.
Katoh T; 1 Department of Public Health, Faculty of Life Sciences, Kumamoto University School of Medicine, Kumamoto, Japan.
Yamaguchi Y; 1 Department of Public Health, Faculty of Life Sciences, Kumamoto University School of Medicine, Kumamoto, Japan.

Hum Exp Toxicol ; 37(6): 596-607, 2018 Jun.

Article em En | MEDLINE | ID: mdl-28673093

Assuntos

Dietilexilftalato/toxicidade; Subunidade p40 da Interleucina-12/metabolismo; Lipopolissacarídeos/farmacologia; Macrófagos/efeitos dos fármacos; Plastificantes/toxicidade; Células Cultivadas; Oxidases Duais/genética; Fator Estimulador de Colônias de Granulócitos e Macrófagos/farmacologia; Humanos; Peptídeos e Proteínas de Sinalização Intracelular; Macrófagos/metabolismo; NADPH Oxidases/genética; PPAR alfa/genética; PPAR alfa/metabolismo; Proteína Quinase C/genética; RNA Interferente Pequeno/genética; Fator 6 Associado a Receptor de TNF/metabolismo; Receptor 4 Toll-Like/genética; Proteína 3 Induzida por Fator de Necrose Tumoral alfa/genética; Proteína 3 Induzida por Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Di-(2-ethylhexyl) phthalate; granulocyte-macrophage colony-stimulating factor; macrophage; peroxisome proliferatoractivated receptor α; tumor necrosis factor receptorassociated factor 6; tumor necrosis factor αinduced protein 3

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Plastificantes / Lipopolissacarídeos / Dietilexilftalato / Subunidade p40 da Interleucina-12 / Macrófagos Limite: Humans Idioma: En Revista: Hum Exp Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google