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Thymoma-associated Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM) with Myasthenia Gravis.
Morise, Satoshi; Nakamura, Masataka; Morita, Jun-Ichi; Miyake, Kousuke; Kunieda, Takenobu; Kaneko, Satoshi; Kusaka, Hirofumi.
Afiliação
  • Morise S; Department of Neurology, Kansai Medical University, Japan.
  • Nakamura M; Department of Neurology, Kansai Medical University, Japan.
  • Morita JI; Department of Neurology, Komatsu Hospital, Japan.
  • Miyake K; Department of Neurology, Kansai Medical University, Japan.
  • Kunieda T; Department of Neurology, Kansai Medical University, Japan.
  • Kaneko S; Department of Neurology, Kansai Medical University, Japan.
  • Kusaka H; Department of Neurology, Kansai Medical University, Japan.
Intern Med ; 56(13): 1733-1737, 2017.
Article em En | MEDLINE | ID: mdl-28674368
We report a case of a 72-year-old woman who initially presented with symptoms of bulbar myasthenia and was positive for anti-acetylcholine receptor antibodies. She subsequently developed painful muscle spasms, myoclonus, and stiffness. Thymoma was detected, and both anti-glycine receptor and anti-glutamic acid decarboxylase antibodies were found. She was diagnosed with thymoma-associated progressive encephalomyelitis with rigidity and myoclonus (PERM). She experienced marked improvement after thymectomy followed by plasma exchange and intravenous immunoglobulin and prednisolone. This case suggests that thymectomy followed by sufficient immunosuppression may be useful in the treatment of thymoma-associated PERM. Myasthenia gravis may develop in thymoma-associated PERM patients.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Timoma / Neoplasias do Timo / Encefalomielite / Rigidez Muscular Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Aged / Female / Humans Idioma: En Revista: Intern Med Assunto da revista: MEDICINA INTERNA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Outros_tipos Base de dados: MEDLINE Assunto principal: Timoma / Neoplasias do Timo / Encefalomielite / Rigidez Muscular Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Aged / Female / Humans Idioma: En Revista: Intern Med Assunto da revista: MEDICINA INTERNA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão