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A Novel Tropoloisoquinoline Alkaloid, Neotatarine, from Acorus calamus L.
Li, Juan; Li, Zhao-Xing; Zhao, Jian-Ping; Wang, Wei; Zhao, Xiao-Fang; Xu, Bo; Li, Lin; Zhang, Lan; Ren, Jie; Khan, Ikhlas A; Li, Shun-Xiang.
Afiliação
  • Li J; Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China.
  • Li ZX; College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, 400715, P. R. China.
  • Zhao JP; National Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA.
  • Wang W; Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China.
  • Zhao XF; Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China.
  • Xu B; Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China.
  • Li L; Key Laboratory of Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing, 100053, P. R. China.
  • Zhang L; Key Laboratory of Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing, 100053, P. R. China.
  • Ren J; Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China.
  • Khan IA; National Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA.
  • Li SX; Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha, 410208, P. R. China.
Chem Biodivers ; 14(10)2017 Oct.
Article em En | MEDLINE | ID: mdl-28695650
A novel tropoloisoquinoline alkaloid, neotatarine (1), was isolated from the 95% ethanol extract of the rhizome parts of Acorus calamus L. The chemical structure was unambiguously elucidated by spectroscopic and single-crystal X-ray diffraction analysis. Neotatarine (1) exhibited significantly inhibitory activity against Aß25 - 35 induced PC12 cell death with 2, 4 and 8 µm comparing with the assay control (P < 0.01).
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Tropolona / Peptídeos beta-Amiloides / Acorus / Isoquinolinas Limite: Animals Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Tropolona / Peptídeos beta-Amiloides / Acorus / Isoquinolinas Limite: Animals Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article