[Role of the human ErbB family receptors in urothelial carcinoma of the bladder: mRNA expression status and prognostic relevance]. / Bedeutung der ERBB-Rezeptorfamilie beim Urothelkarzinom der Harnblase: mRNA-Expression und prognostische Relevanz.
Aktuelle Urol
; 48(4): 356-362, 2017 Aug.
Article
em De
| MEDLINE
| ID: mdl-28750448
ABSTRACT
Background Altered expression of epidermal growth factor (EGF) family (ErbB) receptors in urothelial carcinoma of the urinary bladder (UCB) has been associated with adverse outcomes. Given the limited treatment options in UCB, EGFR and HER2 (ERBB2) represent established therapeutic targets in other entities. We assessed the expression of ErbB family receptors (ERBB1â-â4) on mRNA levels in correlation with histopathological and clinical parameters in patients treated with radical cystectomy (RC). Methods 94 patients (femaleâ=â22; maleâ=â72; median age 66.5 years [range 39â-â88]) with UCB (pT1â-â4) treated with RC were included. Median follow-up was 28.2 months (range 0.6â-â139). ErbB mRNA expression levels were determined after extraction from formalin-fixed, paraffin-embedded tissue. Univariate and multivariate Cox proportional hazard models were performed to assess recurrence-free survival (RFS) and cancer-specific survival (CSS). Results Overexpression was observed in 18â% (ERBB3), 39â% (EGFR), 34â% (HER2, ERBB2) and 30â% (ERBB4) of patients, respectively. Higher pathological stage (pâ=â0.012), a positive nodal status (pâ=â0.0002), high ERBB4 (pâ=â0.012) and high HER2 (ERBB2) levels (pâ=â0.014) were significantly associated with reduced RFS.âA negative lymph node status (pâ=â0.0003) and low HER2 (ERBB2) (pâ=â0.042) levels had a favourable prognostic impact on CSS.âIn multivariate analysis, positive pN stage (pâ=â0.0011) and high ERBB4 (pâ=â0.0073) expression were independent predictors of reduced RFS.âHigher pN stage (pâ=â0.0016) was an independent predictor of reduced CSS. Conclusions Higher HER2 (ERBB2) expression is associated with an unfavourable prognosis in patients with UCB. However, it is not an independent predictor when measured on mRNA levels. Further analyses need to clarify which patients may still benefit from HER2 (ERBB2) targeted drugs.
Texto completo:
1
Coleções:
01-internacional
Temas:
Cuidados_paliativos
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Geral
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Tipos_de_cancer
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Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
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RNA Mensageiro
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Receptores ErbB
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
De
Revista:
Aktuelle Urol
Ano de publicação:
2017
Tipo de documento:
Article