Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair.

Zhao, Min; Wang, Dan-Dan; Che, Yuan; Wu, Meng-Qiu; Li, Qing-Ran; Shao, Chang; Wang, Yun; Cao, Li-Juan; Wang, Guang-Ji; Hao, Hai-Ping

Zhao, Min; Wang, Dan-Dan; Che, Yuan; Wu, Meng-Qiu; Li, Qing-Ran; Shao, Chang; Wang, Yun; Cao, Li-Juan; Wang, Guang-Ji; Hao, Hai-Ping.

Afiliação

Zhao M; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Wang DD; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Che Y; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Wu MQ; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Li QR; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Shao C; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Wang Y; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Cao LJ; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Wang GJ; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
Hao HP; State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.

Acta Pharmacol Sin ; 39(3): 449-458, 2018 Mar.

Article em En | MEDLINE | ID: mdl-28836581

Assuntos

Reparo do DNA/efeitos dos fármacos; Ginsenosídeos/farmacologia; Mitomicina/farmacologia; Rad51 Recombinase/antagonistas & inibidores; Animais; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Regulação para Baixo/efeitos dos fármacos; Sinergismo Farmacológico; Humanos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Camundongos; Fosforilação/efeitos dos fármacos; Rad51 Recombinase/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Pulmao Base de dados: MEDLINE Assunto principal: Mitomicina / Ginsenosídeos / Reparo do DNA / Rad51 Recombinase Limite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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