Clonal deletion of T cell repertoires with specific T cell receptor Vß chains by two endogenous superantigens in NC/Nga mice.
Biosci Biotechnol Biochem
; 81(11): 2160-2163, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28934904
ABSTRACT
Superantigens (SAgs) are powerful T-cell stimulatory proteins. Because an atopic dermatitis (AD) model NC/Nga mice had two endogenous SAgs, namely minor lymphocyte-stimulating locus-1a (Mls-1a) and mouse mammary tumor virus (MMTV)(SHN), SAg-responsive T-cells bearing Vß5.1, Vß6, Vß8.1, Vß8.2, Vß8.3, Vß9, and Vß11 should be endogenously deleted. Here, we discuss that the endogenous SAgs-expression may be involved in AD-sensitivity in NC/Nga mice.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
/
Superantígenos
/
Deleção Clonal
Limite:
Animals
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Assunto da revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Japão