Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-&#945; and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation.

Hernández-Rodas, María C; Valenzuela, Rodrigo; Echeverría, Francisca; Rincón-Cervera, Miguel Ángel; Espinosa, Alejandra; Illesca, Paola; Muñoz, Patricio; Corbari, Alicia; Romero, Nalda; Gonzalez-Mañan, Daniel; Videla, Luis A

Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-α and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation.

Hernández-Rodas, María C; Valenzuela, Rodrigo; Echeverría, Francisca; Rincón-Cervera, Miguel Ángel; Espinosa, Alejandra; Illesca, Paola; Muñoz, Patricio; Corbari, Alicia; Romero, Nalda; Gonzalez-Mañan, Daniel; Videla, Luis A.

Afiliação

Hernández-Rodas MC; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
Valenzuela R; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
Echeverría F; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
Rincón-Cervera MÁ; Lipid Center, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
Espinosa A; Department of Medical Technology, Faculty of Medicine, University of Chile, Santiago, Chile.
Illesca P; Department of Biochemistry, School of Biochemistry, University of Litoral, Santa Fe, Argentina.
Muñoz P; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
Corbari A; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.
Romero N; Faculty of Chemical Sciences and Pharmacy, Department of Food Science and Chemical Technology, University of Chile, Santiago, Chile.
Gonzalez-Mañan D; Molecular and Clinical Pharmacology Program, Institute of Biomedical Science, Faculty of Medicine, University of Chile, Santiago, Chile.
Videla LA; Molecular and Clinical Pharmacology Program, Institute of Biomedical Science, Faculty of Medicine, University of Chile, Santiago, Chile.

Mol Nutr Food Res ; 61(12)2017 12.

Article em En | MEDLINE | ID: mdl-28940752

Assuntos

Ácidos Docosa-Hexaenoicos/farmacologia; Fígado/efeitos dos fármacos; Hepatopatia Gordurosa não Alcoólica/prevenção & controle; Azeite de Oliva/farmacologia; Gordura Abdominal/efeitos dos fármacos; Animais; Dieta Hiperlipídica/efeitos adversos; Suplementos Nutricionais; Regulação para Baixo/efeitos dos fármacos; Ácidos Graxos/metabolismo; Fígado/metabolismo; Fígado/patologia; Masculino; Camundongos Endogâmicos C57BL; Fator 2 Relacionado a NF-E2/metabolismo; NF-kappa B/metabolismo; Hepatopatia Gordurosa não Alcoólica/etiologia; Estresse Oxidativo/efeitos dos fármacos; PPAR alfa/metabolismo; Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo

Palavras-chave

docosahexaenoic acid; extra virgin olive oil; nuclear factor E2-related factor 2; nuclear factor-κB; peroxisome proliferator-activated receptor-α; sterol regulatory element-binding protein 1c

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Texto completo: 1 Coleções: 01-internacional Temas: Agentes_cancerigenos Base de dados: MEDLINE Assunto principal: Ácidos Docosa-Hexaenoicos / Hepatopatia Gordurosa não Alcoólica / Azeite de Oliva / Fígado Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Mol Nutr Food Res Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile

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