Use of Nicardipine After Cardiac Operations Is Safe in Children Regardless of Age.
Ann Thorac Surg
; 105(1): 181-185, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-28987396
ABSTRACT
BACKGROUND:
Control of postoperative hypertension is central to the care of infants and children after cardiac operations. Continuous pharmacologic delivery affords the advantage of rapid onset and ease of titration. Although well established in older children and adults, calcium channel blockers are routinely avoided in children aged younger than 1 year secondary to concerns of safety and efficacy in the setting of sarcoplasmic reticulum development. Thus, the purpose of this study was to review a single-institution experience with nicardipine, a selective calcium channel blocker, in pediatric patients after cardiac operations.METHODS:
Children undergoing cardiac operations at the University of Virginia from 2010 to 2015 were retrospectively reviewed after selection based on receipt of nicardipine for blood pressure management in the postoperative period. Demographic, operative, laboratory, and postoperative data were collected for adverse effect analysis and outcomes comparisons between infants aged younger than 6 months (group 1) and older than 6 months (group 2).RESULTS:
During the study period, 68 children (group 1 n = 33 [48%]; group 2 n = 35 [52%]) received nicardipine after cardiac operations (0.5 to 1 µg · kg-1 · min-1). Nicardipine was initiated at a mean of 6.6 ± 13.1 hours postoperatively in group 1 and 5.4 ± 7.8 hours in group 2. Nine patients (13%) demonstrated clinically significant hypotension necessitating dosing titration with no statistically significant differences between groups. No major adverse events occurred following nicardipine administration.CONCLUSIONS:
Nicardipine is well tolerated after cardiac operations in children irrespective of age or underlying pathology. Thus, nicardipine should be considered as safe and effective in children of all ages for control of hypertension after cardiac operations.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Bloqueadores dos Canais de Cálcio
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Nicardipino
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Procedimentos Cirúrgicos Cardíacos
/
Hipertensão
Tipo de estudo:
Observational_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Ann Thorac Surg
Ano de publicação:
2018
Tipo de documento:
Article