[Survival Benefit by Combined Administration of Cyclophosphamide, Lentinula edodes Mycelia Extract(LEM), and Ganoderma lucidum Mycelia Extract(MAK)in S1018B10 Tumor-Bearing Mice].
Gan To Kagaku Ryoho
; 44(10): 896-899, 2017 Oct.
Article
em Ja
| MEDLINE
| ID: mdl-29066688
Cyclophosphamide(CY)was intraperitoneally administered once a week to C57BL/10mice that had received Rous sarcoma virus(RSV)-induced S1018B10 syngeneic tumor transplantation and in whom tumor diameter exceeded 4.5 mm. Survival was prolonged in a group of mice that also received a mixture of LEM and MAK orally. When splenic cells were cultured under mitomycin C-treated S1018B10 stimulation and the S1018B10-directed cell killing ability was examined, the effector cells were found to be F4/80 - DC/MÑ cells. Flow cytometric analysis showed that the proportion of F4/80- DC/MÑ cells in the splenic cell culture of the CY+LEM+MAK treatment group was higher than that in the untreated group. The ratio of F4/80+ CD8a+ cells in the CY+LEM+MAK treatment group was lower than that in the untreated group.
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Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Lentinula
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Ciclofosfamida
/
Ganoderma
Limite:
Animals
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Ano de publicação:
2017
Tipo de documento:
Article