Three new cytotoxic oleanane triterpenoid saponins from Cylindrokelupha dalatensis.

Yan, Meng-Yun; Liu, Jie; Xing, Shuang; Xiong, Guo-Ling; Pei, Ling-Peng; Ma, Bai-Ping; Liu, Ping; Zhou, Wen-Bin

Yan, Meng-Yun; Liu, Jie; Xing, Shuang; Xiong, Guo-Ling; Pei, Ling-Peng; Ma, Bai-Ping; Liu, Ping; Zhou, Wen-Bin.

Afiliação

Yan MY; a Institute of Minority Traditional Medicine Research , Minzu University of China , Beijing 100081 , China.
Liu J; b Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine , Beijing 100029 , China.
Xing S; c Department of Experimental Therapeutic of Radiation Sickness , Beijing Institute of Radiation Medicine , Beijing 100850 , China.
Xiong GL; c Department of Experimental Therapeutic of Radiation Sickness , Beijing Institute of Radiation Medicine , Beijing 100850 , China.
Pei LP; a Institute of Minority Traditional Medicine Research , Minzu University of China , Beijing 100081 , China.
Ma BP; c Department of Experimental Therapeutic of Radiation Sickness , Beijing Institute of Radiation Medicine , Beijing 100850 , China.
Liu P; d Department of Pharmacy , Hainan Branch of Chinese People's Liberation Army General Hospital , Hainan 572013 , China.
Zhou WB; a Institute of Minority Traditional Medicine Research , Minzu University of China , Beijing 100081 , China.

J Asian Nat Prod Res ; 20(8): 770-780, 2018 Aug.

Article em En | MEDLINE | ID: mdl-29110541

ABSTRACT

ABSTRACT

Three new minor oleanane triterpenoid saponins, cylindrosides B (1), C (2), and D (3), were isolated from the seed of Cylindrokelupha dalatensis using chromatographic method. Their structures were established on the basis of the chemical and spectroscopic evidences. They displayed significant antitumor activity in vitro against HL60 cancer cell lines and IC50 values were 7.15 ± 0.63, 10.07 ± 0.97, and 4.74 ± 0.57 µM, respectively, by MTT method.

Assuntos

Antineoplásicos Fitogênicos/química; Antineoplásicos Fitogênicos/farmacologia; Plantas Medicinais/química; Saponinas/química; Saponinas/farmacologia; Triterpenos/química; Triterpenos/farmacologia; Ensaios de Seleção de Medicamentos Antitumorais; Medicamentos de Ervas Chinesas; Células HL-60; Humanos; Espectroscopia de Ressonância Magnética; Modelos Moleculares; Espectrometria de Massas por Ionização por Electrospray

Palavras-chave

cylindroside B; cylindroside C; cylindroside D; triterpenoid saponin

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Saponinas / Triterpenos / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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