4-Methylthio-3-butenyl isothiocyanate mediates nuclear factor (erythroid-derived 2)-like 2 activation by regulating reactive oxygen species production in human esophageal epithelial cells.

Hirata, Tadashi; Cho, Young-Man; Suzuki, Isamu; Toyoda, Takeshi; Akagi, Jun-Ichi; Nakamura, Yasushi; Numazawa, Satoshi; Ogawa, Kumiko

Hirata, Tadashi; Cho, Young-Man; Suzuki, Isamu; Toyoda, Takeshi; Akagi, Jun-Ichi; Nakamura, Yasushi; Numazawa, Satoshi; Ogawa, Kumiko.

Afiliação

Hirata T; Division of Pathology, National Institute of Health Sciences, Tokyo, Japan; Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, Tokyo, Japan.
Cho YM; Division of Pathology, National Institute of Health Sciences, Tokyo, Japan. Electronic address: ymcho@nihs.go.jp.
Suzuki I; Division of Pathology, National Institute of Health Sciences, Tokyo, Japan; Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
Toyoda T; Division of Pathology, National Institute of Health Sciences, Tokyo, Japan.
Akagi JI; Division of Pathology, National Institute of Health Sciences, Tokyo, Japan.
Nakamura Y; Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Kyoto, Japan.
Numazawa S; Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, Tokyo, Japan.
Ogawa K; Division of Pathology, National Institute of Health Sciences, Tokyo, Japan.

Food Chem Toxicol ; 111: 295-301, 2018 Jan.

Article em En | MEDLINE | ID: mdl-29155359

Assuntos

Células Epiteliais/efeitos dos fármacos; Esôfago/citologia; Isotiocianatos/toxicidade; Fator 2 Relacionado a NF-E2/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Glutationa/metabolismo; Humanos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Sistema de Sinalização das MAP Quinases/fisiologia; Fator 2 Relacionado a NF-E2/genética; RNA Mensageiro/genética; RNA Mensageiro/metabolismo

Palavras-chave

4-Methylthio-3-butenyl isothiocyanate; Chemoprevention; Isothiocyanate; Nuclear factor (erythroid-derived 2)-like 2; Reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Espécies Reativas de Oxigênio / Isotiocianatos / Células Epiteliais / Esôfago / Fator 2 Relacionado a NF-E2 Limite: Humans Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão

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