Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and their evaluation in H<sub>2</sub>O<sub>2</sub>-induced oxidative stress.

Loubidi, Mohammed; Jouha, Jabrane; Tber, Zahira; Khouili, Mostafa; Suzenet, Franck; Akssira, Mohamed; Erdogan, Mümin Alper; Köse, Fadime Aydin; Dagci, Taner; Armagan, Güliz; Saso, Luciano; Guillaumet, Gérald

Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and their evaluation in H₂O₂-induced oxidative stress.

Loubidi, Mohammed; Jouha, Jabrane; Tber, Zahira; Khouili, Mostafa; Suzenet, Franck; Akssira, Mohamed; Erdogan, Mümin Alper; Köse, Fadime Aydin; Dagci, Taner; Armagan, Güliz; Saso, Luciano; Guillaumet, Gérald.

Afiliação

Loubidi M; Institut de Chimie Organique et Analytique, Université d'Orléans, UMR-CNRS 7311, BP 6759, rue de Chartres, 45067, Orléans Cedex 2, France; Equipe de Chimie Bioorganique & Analytique, URAC 22 Université Hassan II Mohammedia-Casablanca, BP 146, 28800, Mohammedia, Morocco.
Jouha J; Institut de Chimie Organique et Analytique, Université d'Orléans, UMR-CNRS 7311, BP 6759, rue de Chartres, 45067, Orléans Cedex 2, France; Laboratoire de Chimie Organique et Analytique, Université Sultan Moulay Slimane - Faculté des Sciences et Techniques, BP 523, 23000, Beni-Mellal, Morocco.
Tber Z; Institut de Chimie Organique et Analytique, Université d'Orléans, UMR-CNRS 7311, BP 6759, rue de Chartres, 45067, Orléans Cedex 2, France.
Khouili M; Laboratoire de Chimie Organique et Analytique, Université Sultan Moulay Slimane - Faculté des Sciences et Techniques, BP 523, 23000, Beni-Mellal, Morocco.
Suzenet F; Institut de Chimie Organique et Analytique, Université d'Orléans, UMR-CNRS 7311, BP 6759, rue de Chartres, 45067, Orléans Cedex 2, France.
Akssira M; Equipe de Chimie Bioorganique & Analytique, URAC 22 Université Hassan II Mohammedia-Casablanca, BP 146, 28800, Mohammedia, Morocco.
Erdogan MA; Department of Physiology, Faculty of Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
Köse FA; Department of Biochemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey.
Dagci T; Department of Physiology, Faculty of Medicine, Ege University, 35100, Bornova, Izmir, Turkey.
Armagan G; Department of Biochemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey.
Saso L; Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.
Guillaumet G; Institut de Chimie Organique et Analytique, Université d'Orléans, UMR-CNRS 7311, BP 6759, rue de Chartres, 45067, Orléans Cedex 2, France. Electronic address: gerald.guillaumet@univ-orleans.fr.

Eur J Med Chem ; 145: 113-123, 2018 Feb 10.

Article em En | MEDLINE | ID: mdl-29324335

Assuntos

Peróxido de Hidrogênio/antagonistas & inibidores; Imidazóis/farmacologia; Triazinas/farmacologia; Apoptose/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Humanos; Peróxido de Hidrogênio/farmacologia; Imidazóis/síntese química; Imidazóis/química; Estrutura Molecular; Estresse Oxidativo/efeitos dos fármacos; Estereoisomerismo; Relação Estrutura-Atividade; Triazinas/síntese química; Triazinas/química; Células Tumorais Cultivadas

Palavras-chave

Akt signaling; Apoptosis; CH arylation; Cyclocondensation; Oxidative stress; Regioselective; imidazo[2,1-c][1,2,4]triazines

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Triazinas / Peróxido de Hidrogênio / Imidazóis Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Marrocos

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