Structural Insights in Multifunctional Papillomavirus Oncoproteins.
Viruses
; 10(1)2018 01 15.
Article
em En
| MEDLINE
| ID: mdl-29342959
ABSTRACT
Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7 have been recalcitrant to high-resolution structure analysis. However, in the last decade a wealth of three-dimensional information has been gained on both proteins whether free or complexed to host target proteins. Here, we first summarize the diverse activities of these small multifunctional oncoproteins. Next, we review the available structural data and the new insights they provide about the evolution of E6 and E7, their multiple interactions and their functional variability across human papillomavirus (HPV) species.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Proteínas Repressoras
/
Proteínas Oncogênicas Virais
/
Proteínas E7 de Papillomavirus
Limite:
Humans
Idioma:
En
Revista:
Viruses
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França