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Opposing roles of TGFß and BMP signaling in prostate cancer development.
Lu, Xin; Jin, Eun-Jung; Cheng, Xi; Feng, Shan; Shang, Xiaoying; Deng, Pingna; Jiang, Shan; Chang, Qing; Rahmy, Sharif; Chaudhary, Seema; Lu, Xuemin; Zhao, Ren; Wang, Y Alan; DePinho, Ronald A.
Afiliação
  • Lu X; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Jin EJ; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana 46556, USA.
  • Cheng X; Tumor Microenvironment and Metastasis Program, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA.
  • Feng S; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Shang X; Department of Biological Science, Wonkwang University, Cheonbuk, Iksan 570-749, South Korea.
  • Deng P; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana 46556, USA.
  • Jiang S; Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Chang Q; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana 46556, USA.
  • Rahmy S; School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Chaudhary S; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Lu X; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Zhao R; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Wang YA; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • DePinho RA; Department of Biological Sciences, Boler-Parseghian Center for Rare and Neglected Diseases, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Genes Dev ; 31(23-24): 2337-2342, 2017 12 01.
Article em En | MEDLINE | ID: mdl-29352019
ABSTRACT
SMAD4 constrains progression of Pten-null prostate cancer and serves as a common downstream node of transforming growth factor ß (TGFß) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFß receptor II (TGFBR2) and BMP receptor II (BMPR2) using a Pten-null prostate cancer model. These studies demonstrated that the molecular actions of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis. In contrast, BMPR2 deletion extended survival relative to Pten deletion alone, establishing its promoting role in BMP6-driven prostate cancer progression. These analyses reveal the complexity of TGFß-BMP signaling and illuminate potential therapeutic targets for prostate cancer.
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Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Prostata Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Transdução de Sinais / Proteínas Serina-Treonina Quinases / Receptores de Fatores de Crescimento Transformadores beta / Receptores de Proteínas Morfogenéticas Ósseas Tipo II Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Temas: Geral / Tipos_de_cancer / Prostata Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Transdução de Sinais / Proteínas Serina-Treonina Quinases / Receptores de Fatores de Crescimento Transformadores beta / Receptores de Proteínas Morfogenéticas Ósseas Tipo II Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos