Plasmacytoid dendritic cells: important players in human kidney allograft rejection.
Kidney Int
; 93(2): 301-303, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29389394
ABSTRACT
Plasmacytoid dendritic cells are a unique dendritic cell subset that bridges innate and adaptive immune responses. They release high amounts of type I interferons in response to viral and bacterial infection. Plasmacytoid dendritic cells are thought to act as key players in renal allograft rejection, but the underlying mechanisms are unclear. Ruben et al. now demonstrate that granulocyte/macrophage colony-stimulating factor produced by renal epithelial cells is important to induce plasmacytoid dendritic cell maturation and indirect antigen presentation triggering allogeneic immune responses.
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Aloenxertos
Limite:
Humans
Idioma:
En
Revista:
Kidney Int
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Alemanha