Neonatal Cushing Syndrome: A Rare but Potentially Devastating Disease.
Clin Perinatol
; 45(1): 103-118, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29406000
ABSTRACT
Neonatal Cushing syndrome (CS) is most commonly caused by exogenous administration of glucocorticoids and rarely by endogenous hypercortisolemia. CS owing to adrenal lesions is the most common cause of endogenous CS in neonates and infants, and adrenocortical tumors (ACTs) represent most cases. Many ACTs develop in the context of a TP53 gene mutation, which causes Li-Fraumeni syndrome. More rarely, neonatal CS presents as part of other syndromes such as McCune-Albright syndrome or Beckwith-Wiedemann syndrome. Management usually includes resection of the primary tumor with or without additional medical treatment, but manifestations may persist after resolution of hypercortisolemia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
/
Tipos_de_cancer
/
Outros_tipos
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Córtex Suprarrenal
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Carcinoma Adrenocortical
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Adenoma Adrenocortical
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Síndrome de Cushing
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
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Newborn
Idioma:
En
Revista:
Clin Perinatol
Ano de publicação:
2018
Tipo de documento:
Article