Cell Density-Dependent Cytological Stage Profile and Its Application for a Screen of Cytostatic Agents Active Toward Leukemic Stem Cells.

Lica, Jan J; Grabe, Grzegorz J; Heldt, Mateusz; Misiak, Majus; Bloch, Patrycja; Serocki, Marcin; Switalska, Marta; Wietrzyk, Joanna; Baginski, Maciej; Hellmann, Andrzej; Borowski, Edward; Skladanowski, Andrzej

Lica, Jan J; Grabe, Grzegorz J; Heldt, Mateusz; Misiak, Majus; Bloch, Patrycja; Serocki, Marcin; Switalska, Marta; Wietrzyk, Joanna; Baginski, Maciej; Hellmann, Andrzej; Borowski, Edward; Skladanowski, Andrzej.

Afiliação

Lica JJ; 1 Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology , Gdansk, Poland .
Grabe GJ; 2 Department of Medicine, Imperial College London , London, United Kingdom .
Heldt M; 1 Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology , Gdansk, Poland .
Misiak M; 1 Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology , Gdansk, Poland .
Bloch P; 1 Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology , Gdansk, Poland .
Serocki M; 1 Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology , Gdansk, Poland .
Switalska M; 3 Department of Biology and Pharmaceutical Botany, Medical University of Gdansk , Gdansk, Poland .
Wietrzyk J; 4 Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy , Polish Academy of Sciences, Wroclaw, Poland .
Baginski M; 4 Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy , Polish Academy of Sciences, Wroclaw, Poland .
Hellmann A; 1 Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology , Gdansk, Poland .
Borowski E; 5 Department of Hematology and Transplantology, Medical University of Gdansk , Gdansk, Poland .
Skladanowski A; 1 Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology , Gdansk, Poland .

Stem Cells Dev ; 27(7): 488-513, 2018 04 01.

Article em En | MEDLINE | ID: mdl-29431006

Assuntos

Ciclo Celular/efeitos dos fármacos; Diferenciação Celular/efeitos dos fármacos; Citostáticos/farmacologia; Células-Tronco Neoplásicas/efeitos dos fármacos; Doença Aguda; Animais; Contagem de Células; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Citostáticos/química; Resistencia a Medicamentos Antineoplásicos; Ensaios de Seleção de Medicamentos Antitumorais/métodos; Células HL-60; Humanos; Leucemia Mieloide/metabolismo; Leucemia Mieloide/patologia; Camundongos Endogâmicos BALB C; Camundongos Nus; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

HL-60; anthrapyridazones; cell culture density-dependent cytological stage profile; drug screening platform; leukemic stem; progenitor and precursor cells; transporter-mediated multidrug resistance

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Texto completo: 1 Coleções: 01-internacional Temas: Geral Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Ciclo Celular / Diferenciação Celular / Citostáticos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Stem Cells Dev Assunto da revista: HEMATOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Polônia

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